It's important to consider how a flare unfolds. At the very beginning, symptoms may appear to be very mild and remain so for a day or two before more serious problems appear. Typically, peak flow rates will begin to drop at the same time that symptoms increase. Sometimes the very first sign that a flare might begin is the appearance of a common cold or upper respiratory tract symptoms, such as runny nose, nasal congestion, or fever. Be aware, however, that not every cold virus will trigger an asthma flare. Also remember that as a child gets older, cold symptoms can be very mild or absent, even though a virus has infected the respiratory tract and will trigger a new asthma flare. In this case, the presence of nasal symptoms is not a useful clue.
When an asthma flare becomes severe, virtually all children will have either a cough or other lung-specific symptoms (such as wheezing) late at night usually after midnight. These nighttime symptoms can last for one or two nights in milder flares or much longer with severe flares. And as a new flare begins to get better, coughing and other symptoms during this midnight-to-6-A.M. time frame begin to disappear. This decrease should reassure you that a flare is changing for the better, and the medicine plan is working. If symptoms don't improve during this time frame, look at your plan again. More medicine and perhaps monitoring may be indicated, so let your doctor or nurse practitioner know of your concern.
Parents and children are often confused and frightened when symptoms reach their fullest expression late at night. Why do symptoms get worse after midnight or in the early morning hours? An asthma flare rep-resents increased inflammation in the lungs.
Protective mechanisms against inflammation decrease. Blood levels of cortisol and adrenaline decrease during this time, allowing inflammation to increase. Another reason that symptoms flare is the tendency of the lungs' airways to be "twitchy" or tighten easily. This is called "airway hyper-reactivity." Simple things like laughing or crying hard, running and playing or breathing cold air make a child cough, get short of breath, wheeze, or have chest tightness or pain. If there is enough closure of the airway, this obstruction causes more severe shortness of breath. This "twitchiness" is the first symptom to appear with a new flare and the last to leave. In fact, with any asthma flare, an increase in lung twitchiness can last for days or even weeks. A child who is completely well between cold virus—triggered flares might have the tendency to cough easily for a prolonged time after a flare. After nighttime cough is gone, the child usually begins an increase in daytime activity like play-ing outside. When he comes in for dinner, he might cough all evening before midnight. It might seem that a new flare is starting, but after mid-night there are no symptoms. In this common situation, a child needs only some quick-relief medicine before bedtime. If no new symptoms occur after midnight, a new flare is not beginning. This youngster only has a temporary increase in "twitchiness" from his last flare. Increased production of mucus by the lungs is another reason that symptoms occur during asthma flares. This happens at the beginning of a flare, but the excess mucus will not flow up the bronchial tree very well until the severe tightening of the airways begins to decrease. When the flare is at its height, a child may cough as though he wants to get some-thing out of his chest, but nothing may come up. Later when the airways are more open, or after a bronchodilator treatment opens them farther, mucus begins to travel upward more easily. This may cause cough in itself Thick mucus secretions need forceful coughs to move upward through narrow passageways. Often a treatment with albuterol or other bronchodilator may increase the cough because lung secretions are loos-ened. This is to be expected and should not be a cause for alarm unless the cough and choking is not relieved within a brief period of time. After night coughing diminishes, airways are typically more open,
and coughs caused by "loose" secretions of mucus become more promi-nent. Coughing usually occurs upon waking in the morning, and a "loose" cough appears during the day. This pattern should not be con-fused with mucus made in the nose or postnasal drip because the lungs make their own mucus. Typically, the period of time when a child shows symptoms from increased airway mucus will end before the extra twitchiness does.
At best, no signs such as nighttime cough or increased mucus should be present between flares. If symptoms begin and quick-relief medicines are needed, a new flare likely has begun, and your management plan should be started. Remember that any child who has daily symptoms of severe persistent asthma will have trouble detecting the start of a new flare. These children have most symptoms on a daily basis, including night cough. Their symptoms don't turn on and off, and therefore these children have significant difficulty knowing when to begin their manage-ment plans. For these youngsters to successfully manage their asthma, daily symptoms (especially the nighttime symptoms) need to be reduced by adjusting daily controller medicines and environmental controls.
"" When Caryn woke up the next morning, she seemed a little better. She said she felt fine and was eager to go to school because her class was having a special art program that afternoon. Caryn only coughed once or twice during breakfast, so her parents—needing to rush to work themselves—sent her off to meet the school bus and forgot about calling the pediatrician. That night Caryn woke up coughing hard at four o'clock. She went to her parents' room and told them she was having a lot of trouble breathing. The scared look on her face alarmed her parents. They dialed the pediatrician's number, got the answering service, and explained that they thought this could be an emergency.When the doctor called back a few minutes later, she asked Caryn's mother about the symptoms—what they were, how long they'd lasted—and asked if Caryn had begun her asthma management plan for flares. Her mother immediately realized that she hadn't even thought "asthma." She'd been assuming all along that this was just a cold! The pediatrician told her to give Caryn albuterol immediately for quick relief and to increase the dose of Flo vent, the inhaled corticosteroid specified in Caryn's asthma management plan, and to continue using this anti-inflammatory medicine for the next five to seven days. The pediatrician called back a few days later to see how Caryn was doing. The albuterol had helped, she'd started the increased dose of Flo vent, but she still had some nighttime coughing for two more nights, so her parents had decided to keep her home from school for two days.The doctor reminded her mother that Caryn was close to needing a course of oral steroids and told her to review Caryn's asthma management plan and immediately take action when symptoms arise or change in the future. Caryn's mother said she was embarrassed that she hadn't linked her daughter's recent symptoms to asthma. "It's easy to overlook," the doctor replied, "because Caryn's asthma has been under good control for months. But the key is to recognize symptoms quickly and notice any changes in symptom patterns because they can signal the beginning of a flare. Even symptoms of a cold can be asthma triggers, and you want to take control sooner rather than later? ""